Electrophysiology & equipment
I have more than 20 years of experience in electrophysiology. Specifically, I can advise on following:
1) patch clamp recordings;
2) extracellular recordings in vivo, from brain slices, nerves and muscles;
3) capacitance and amperometry measurements;
4) the choice of equipment for the above recordings;
5) electrophysiological data analysis.
In addition, I have designed a number of electronic instruments for electrophysiological and behavioral experiments. Specifically, I can design and build:
1) electrophysiological amplifiers;
2) stimulus isolators;
3) perfusion and solenoid controllers;
4) controllers for stepper and servo motors;
5) LED drivers for optogenetics;
6) temperature controllers;
7) power supplies;
8) Arduino-based devices for experiment control and automation.
1) patch clamp recordings;
2) extracellular recordings in vivo, from brain slices, nerves and muscles;
3) capacitance and amperometry measurements;
4) the choice of equipment for the above recordings;
5) electrophysiological data analysis.
In addition, I have designed a number of electronic instruments for electrophysiological and behavioral experiments. Specifically, I can design and build:
1) electrophysiological amplifiers;
2) stimulus isolators;
3) perfusion and solenoid controllers;
4) controllers for stepper and servo motors;
5) LED drivers for optogenetics;
6) temperature controllers;
7) power supplies;
8) Arduino-based devices for experiment control and automation.
Below are some examples of electronic instuments that I created recently.
Moving doors for the mouse maze.
The maze has 2 moving doors actuated when the mouse passes and activates the PIR sensors, after the required time delays. In addition, the motorized syringe pump is used for reward administration.
Mouse whisker/sound/light stimulator.
The device allows the stimulation of mouse whiskers on the left and the right side of the head, with a random order, after a trigger is received. The stimulation is done with the help of 2 stepper motors. In addition, sound and light stimulation is also possible.
Electrophysiological amplifiers.
Many units of different electrophysiological amplifiers were built, for use in LFP, EEG, EMG, and ECG recordings.
An example EEG record obtained from anesthethized mouse with one of these amplifiers:
An example of field EPSP recordings from CA1 hippocampal region of the anesthethized mouse:
Amplifier for the Ear-Bot, the hybrid biorobot that utilizes the locust ear.
The robot moves in response to the sound. As an acustic sensor, the auditory organ of locust is used. The signal is recorded from the auditory nerve with the help of the extracellular electrodes and amplified with the extracellular amplifier (please see the PC screen on the right side of the video). My part in this work was to design and build this amplifier. After further processing, the amplified signal is used to command the movement of the robot. The work was published recently:
Fishel I, Amit Y, Shvil N, Sheinin A' Ayali A, Yovel Y, Ben Maoz BM. Ear-Bot: Locust Ear-on-a-Chip Bio-Hibrid Platform. Sensors (Basel). 2021 Jan 1; 21(1):228. doi: 10.3390/s21010228
IOT (Internet-of-Thing) control system for the water chillers of TAU MRI facility.
The controller allows monitoring the operation and switching between 2 water chillers and electrical valves in a distance, online, and also authomatically, according to the pre-defined schedule. The uninterruptible operation of the chillers is important for the correct functioning of the MRI scanner.
Photomultiplier power supply.
Low noise regulated power supply for the Hamamatsu's H10770A PMT.
